Efficacy and safety of lipid-lowering therapies in combination with or without statin to reduce the cardiovascular risk: A systematic review of randomised controlled trials

Background and aims: Cardiovascular diseases (CVD) pose a significant global health burden.Lowering low-density lipoprotein-cholesterol is the primary therapeutic aim for preventing primary and secondary CVD events.While statins are the standard treatments, their limitations, such as side effects and intolerance in certain patient groups, necessita

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Delayed Diagnosis of Osteonecrosis of the Jaw (ONJ) Associated with Bevacizumab Therapy in Colorectal Cancer Patients: Report of Two Cases

Medication-induced Osteonecrosis of the Jaw (MRONJ) has been reported not only after use of antiresorptive agents (bisphosphonates and denosumab), but also in cancer patients receiving antiangiogenic agents, alone or combined with antiresorptive drugs.We report two cases of MRONJ observed in colorectal cancer patients after bevacizumab therapy only

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